TurboGears 2 is a web framework, but unlike some of its competitors, it's not a monolithic unit, it's a collection of libraries, WSGI components, and web development tools that works well together and is configured to provide a great out of the box.
Pyhew is a web framework written in python aiming to ease the web development with python. Based on frameworks like smarty and php2go. Provides a Templating system, forms (with xml for html and validation), url routing and more.
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Leilany is a framework to build GUI applications with Python and GTK, using de MVC pattern design. Interested in build the gadgets for invoicing and the necessary requirements. The main goal is make applications with low memory.
Top Engine the Semantic Web Engine for the Enterprise. Top Engine is a Business Rule Engine that utilize OWL DL ontologies for vocabulary primitive to write rules on top of ontology. Top Engine support forward and backward chaining with truth maintenance
Drupy is a Python implementation of the Drupal content management system. This project is no longer maintained. You can find the original codebase at https://github.com/brendoncrawford/drupy/
An environment (library + IDE) that emulates Delphi but uses python as the programming language and wxPython as the graphical API. Starting with the library, we have a set of modules/classes that emulates the units/classes of the famous VCL.