A content generation engine written in Python used for generating content for HTML and textual output. Integrates with Apache to form a web framework that uses XML templates and can embed Python.
NiL is a modular multi-purpose gaming engine including a multiplayer worm game a little like quake, except it's 2d and a little like worms except it's realtime.
Top Engine the Semantic Web Engine for the Enterprise. Top Engine is a Business Rule Engine that utilize OWL DL ontologies for vocabulary primitive to write rules on top of ontology. Top Engine support forward and backward chaining with truth maintenance
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Eynhorn is a 3d action rpg engine / framework. It will support dialog system, fight system, armors and weapons, and will include a map assembly. It is realized in Soya 3d and Python, so it'll be platform independent.
mgE3D - mgEngine3D is an unfinished 3D Engine based on OpenGL. By now
it provided several features like scenetree, mesh/skeleton mesh rendering and animation, terrain, materials, textures, multiple viewports, Python exporter for Blender and so on.
Spoor is a lightweight, highly-customizable wiki engine with support for dynamically creating fields for structured data. It is written in Python and utilizes the Django web framework.