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vhdPLUS Development Framework is a modern, fully component oriented simulation engine and middleware solution created by and reflecting many years of the R&D experience of both the MIRALab, University of Geneva and VRlab, EPFL labs in the domain of VR/AR
QuickDicom is an easy to use dicom medical imaging package for Mac OSX, providing QuickLook, Spotlight, Quartz Composer, Window/Level and a dicom file analyzer. Also included is the iiDicom Framework for image/dictionary usage in Objective C and Python.
A codebase for the construction of 3d online virtual worlds. Includes everything you need to make your own multiplayer online roleplaying game. All game rules are contained in plugins which can be written in easy scripting languages such as Python.
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A platform independent framework to remote control Lego Mindstorms NXT from Python.
Using PyBluez http://org.csail.mit.edu/pybluez/ for Bluetooth connectivity and wxPython http://www.wxpython.org/ for UI.
Surge is the name of an advanced game engine--includes graphics, sound, physics, scripting, networking, and more. Surge is also the name for the first game for this engine, which will be based on a replacement until the Surge Engine becomes viable.
Spineless is a generic cross-platform 3D game engine implemented in Python. Focus is on flexibility, clean design and ease of use, not pure speed or bleeding edge graphics.
Black Wings is a framework built over SDL to make the game/graphical application development easier, by adding a scene system, an event manager, a template manager and a widget system ready to play with, along with many smaller controls.
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yuik is an abstract widget library for creating GUIs. The actual frontend can be chosen at runtime which allows the program to run under Tk, as a shell program, and even as a web-application. More frontends like an irc-bot, wxWidgets, or XUL are planned.
wxBrowser is an application browser based on the wxWidgets GUI framework. It's similar to a regular old web browser only, instead of reading HTML and displaying content it reads XML and executes presentation logic (wxPython) in a client side application.
ACDK - Artefaktur Component Development Kit - is a platform independent C++-framework similar to Java or C#/.NET for generating distributed and scriptable components and applications.
InterPython (stands Python InterOperability) is a .NET library that allows a python interpreter to be "embedded" in your .NET programs, and gives you (almost) transparent access to python libraries and services in .NET programs. Great for GUIs, etc.
mgE3D - mgEngine3D is an unfinished 3D Engine based on OpenGL. By now
it provided several features like scenetree, mesh/skeleton mesh rendering and animation, terrain, materials, textures, multiple viewports, Python exporter for Blender and so on.
Eynhorn is a 3d action rpg engine / framework. It will support dialog system, fight system, armors and weapons, and will include a map assembly. It is realized in Soya 3d and Python, so it'll be platform independent.
a tool-kit for creating "web 2.5 generation", include several useful stuff to work with semantic web (otology editor, gui for sparql query, ontology components...) and design RIAs's gui visually (html + ajax based apps, flash based apps,...)
Provides a voice interface for applications via a plug in system. Allows the inclusion of voice recognition in an application with a minimum of effort.
An environment (library + IDE) that emulates Delphi but uses python as the programming language and wxPython as the graphical API. Starting with the library, we have a set of modules/classes that emulates the units/classes of the famous VCL.
The PyQt4D (Python Qt for Designer) is an Open Source Project making Qt Designer full-featured RAD (Rapid Application Development) tool to develop data-aware two- or multi-tier applications using Python language and Qt library.