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...It has popular language bindings for Python, Perl, Ruby and many other languages, and unlike other cross-platform toolkits, wxWidgets gives applications a truly native look and feel because it uses the platform's native API rather than emulating the GUI. It's also extensive, free, open-source and mature.
openQA is an automated testing framework designed to test the entire operating system, including the installation process and graphical user interfaces. It is particularly useful for testing complex scenarios that require interaction with the system's GUI.
Mojo-Weixin is a Perl-based, command-line client framework for Weixin (WeChat), built using Mojolicious. It provides an HTTP API interface through plugins to control WeChat accounts programmatically, without requiring a GUI. Built using the Mojolicious web framework for asynchronous handling. Plugin architecture enabling extended functionality and HTTP-based automation. Compatible across systems via Perl and Mojolicious support. Suitable for scripting, integration, or headless operations with WeChat accounts.
Crystal Space is an Open Source 3D SDK for Unix, Windows, and MacOS/X. It renders with OpenGL and features GLSL shaders, CG shaders, deferred rendering, dynamic shadows, bullet based physics library, terrain engine, skeleton based animation meshes, exporter for Blender, portals, etc...
Perl Toolkit for appleJuice ist ein Perl Werkzeugsammlung rund um appleJuice. Ein Teil des Toolkits ist u.a. ApfLi (GUI) und AJ::Data (Perl Schnittstelle zum Core).
Atomic OS is a responsive Web 2.0 operating environment & development platform. Based on AJAX techniques, it emulates/provides standard operating system features including a command-line shell, interpreter, filesystem, database access and GUI services.
pUniConf is a rapid application development (RAD)framework for writing GUI applications in Perl/Gtk2, using plugins as the main source of interface design. Perl modules are coming soon, eliminating the need for plugins!