The TuxCap Games Framework is a GNU/Linux and Mac OSX port of the PopCap Games Framework used for 2D game development. It comes with PyCap Python bindings, a fast 2D physics engine, a particle engine, widgets and many documented examples.
Pyzzle is a cross-platform game engine for creating large-scale, 2D Myst-like adventure games. The engine supports 2D panoramas, features an intuitive design mode, and allows users to download content from the internet. Pyzzle is written using Pygame.