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FrozenPop is a simple and easy to use POP3/SMTP server. Geared to accommodate multiple domains without having to create individual system accounts, FrozenPop installs < 5 mins. With MySQL authentication, creating users is simple.
Amphora Light is a Web-based groupware server written in Python and Zope. It offers basic office functionality: document sharing, calendars, tasks, contacts, internet databases in the context of a hierarchical organization and flexible access rights.
IMAP4 server working on top of SQL database (currently PostgreSQL but Oracle may work too). It has some unique features like elimination of duplicate messages throughout the whole system, possibility of clustering or load balancing etc.
Actim is an application written in python that allows sending/receiving files and calling command lines via email. (under GPL license)
For example, if your home PC does not have any access to your office workstation which is behind the company firewall.
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mailgate is a set of Python scripts we used at my former company to transfer email a) from a POP3 account to our internal mail server, b) from a POP3 account to a mailbox file and c) from a mailbox file to a SMTP server.
JEEPERS (Jason's Extra Easy to Program Email Response System) uses a POP3 email account to monitor email for command phrases in subject lines. Default commands for remote file storeage and retrival. (Nothing to do with mailing lists or mass emailing.)