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JaMaRe (JaMaRe ain't a Mail Reader) has grown out of my own need for a hacker's mail filter. JaMaRe has it's own internal mail folder system, and a very extensible filtering system. JaMaRe can also be used as Mail Router.
chill is a heavy-module-based web-application with a core supporting many features. writing own modules for... everything. modules for webmail, firewall/router-administration, server-administration are planned natively.