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Lotus Notes e-mail (or any other document) notifier. Agent notifying about new emails through XMMP (used by Jabber IM service) protocol. Open architecture allows to write your own plugins supporting other types of communication channels.
"distribution" is a message and data processing tool. It allows to process information through a graph of processors. It may be used to build mailing lists, fax gateways, email filters, PDF mailing combinators, report systems and many other processes
CPO is a tool written in Java that manages newsletters. It's focused on corporate needs (privacy, scalability, bounce count, opt-in & out, newsletter statistics).
Deep Six is a client side spam filtering tool that monitors your inbox for new email and filters it. The modular filter plugin-system allows for greater spam detection. Currently supports SpamBouncer, Vipul's Razor and DCC.
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A mail filtering tool that uses PerlMX to allow fine-grained spam filtering controls. Utilizes host-based blocks as well as heuristics. Can be modified to use Sendmail::Milter.