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TMDA is an open source anti-spam system and local mail delivery agent written in 100% pure Python. TMDA combines whitelists, blacklists, a challenge/response system, and special-purpose e-mail addresses called "tagged addresses" to thwart spam.
Konfidi is a trust framework that uses topical trust values from a social network of authenticated people. When you receive an email from someone you do not know, but he/she is in the network, Konfidi will compute an inferred trust value for you.
elspy is an extension to the Exim MTA that allows Exim users to supply a local_scan() function written in Python instead of C. (Exim's local_scan() API lets sysadmins supply site-specific code for approving/rejecting email messages at SMTP time.)
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SpamGAME is a statistical spam filter based on the GA.M.E. (GAussian Mono-dimensional Environment) algorithm for Text Categorization.
It is written in Python and it should run on all platform having a Python interpreter.
Active Spam Killer for Windows (AfW) is a challenge/response spam filtering system for the Windows platform. Based on ASK for Linux by Marco Paganini, this project adds a POP3 client/server wrapper and web administration, as well as Windows compatibility
Mailchecker will (in time) check mail for 'safe' content. 'unsafe' content (e.g. attachments that may contain viruses) will be stopped or converted to 'safe' formats.