Cypht
Lightweight Open Source webmail written in PHP and JavaScript
... and send outbound messages with SMTP. Cypht is an application built entirely of plugins, or as we call them, module sets (which is obviously way cooler sounding than plugins), that are executed by the framework. Modules provide a flexible way to add new features or customize the program without hacking the code. Cypht is Open Source (LGPL V2), and written in PHP and JavaScript.