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Aspose.Email allows you to work with IMAP, POP and Exchange emails
Email Processing in ASP.NET is a web application that demonstrates some of the great features of Aspose.Email for .NET. This application will practically show you the power and ease of use for working with emails from within your .NET applications.
Edbrowse is a comprehensive editor, browser, and email client that provides access to the net through a command line interface, appropriate for speech or braille. It also supports scripting, to interact with the net in the background, or in batch mode.
Spamato is a spam filter system that combines several anti-spam techniques, from which thousands of users benefit. It is available as an add-on for Thunderbird and Outlook, and as a stand-alone proxy for other email clients. IMAP and POP are supported.
...It uses a POP3 or IMAP servers as the mailstore and sends mail through a SMTP server. You can compose HTML messages, search your inbox, read complex mime messages and much more. .NET and Mono compatible.
Nikita is a peer-to-peer PIM. It will offer all the same benefits of the standard PIMS (such as Outlook or Chandler) but will not require a central server. Items can be marked as Calendar, Task, Email, etc... or any combination of those. Silos be gone!