The ASCO project aims to bring circuit optimization capabilities to existing SPICE simulators using a high-performance parallel differential evolution (DE) optimization algorithm. It supports Eldo, HSPICE, LTspice, Spectre, and Qucs.
Call for the specifications of (next generation of spice) spice4. The concept of spice kernel is proposed. The main function of spice kernel is to provide a communication between "application layer" and "low-level Algorithm layer".