Pyzzle is a cross-platform game engine for creating large-scale, 2D Myst-like adventure games. The engine supports 2D panoramas, features an intuitive design mode, and allows users to download content from the internet. Pyzzle is written using Pygame.
The Deadlock Engine, or DEngine, is a generic, cross-platform isometric game engine written in Python.
wxBeOS tries to port wxwidgets to Zeta/Haiku/BeOS