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Shakya is a Free Software (GPL) framework for easy and quickly building powerfull applications with Python and PyGTK. Besides, there is also an IDE, made with this same framework, thus users can graphically desing Shakya/PyGTK applications.
Sakura is a Knowledge Navigator and User Interface for UNIX, which implements HyperMedia and its own windowing and packing system, both in the main program and in an extensive API for Tcl and other languages.
RGnome is a gtk based frontend for GNU R, which is a widely used language for statistical computing. It features a fully working R console and an editor with syntax highlighting.