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Algernon is a rule-based reasoning engine written in Java. It allows forward and backward chaining across Protege knowledge bases. In addition to traversing the KB, rules can call Java functions and LISP functions (from an embedded LISP interpreter)
OntoCardio is an initiative to build ontologies for the legacy Cardio Database (Resource of bioinformation on cardiovascular diseases). SMI's Protege and its OWL plug-in has been adopted as the ontology construction and programming framework.