Search Results for "knowledge"

...The goal of NicheNet is to study intercellular communication from a computational perspective. NicheNet uses human or mouse gene expression data of interacting cells as input and combines this with a prior model that integrates existing knowledge on ligand-to-target signaling paths. This allows to predict ligand-receptor interactions that might drive gene expression changes in cells of interest. This model of prior information on potential ligand-target links can then be used to infer active ligand-target links between interacting cells. NicheNet prioritizes ligands according to their activity (i.e., how well they predict observed changes in gene expression in the receiver cell) and looks for affected targets with high potential to be regulated by these prioritized ligands.

Hetionet is a hetnet — network with multiple node and edge (relationship) types — which encodes biology. The hetnet was designed for Project Rephetio, which aims to systematically identify why drugs work and predict new therapies for drugs. The JSON and Neo4j formats contain node and edge properties, which are absent in the TSV and matrix formats, including licensing information. Therefore the recommended formats are JSON and Neo4j. Our hetio package in Python reads the JSON format, but it...

The Bio2RDF project aims to transforms silos of life science data into a globally distributed network of linked data for biological knowledge discovery. Bio2RDF creates and provides machine understandable descriptions of biological entities using the RDF/RDFS/OWL Semantic Web languages. Using both syntactic and semantic data integration techniques, Bio2RDF seamlessly integrates diverse biological data and enables powerful new SPARQL-based services across its globally distributed knowledge bases.

INDUS is a porject for knowledge acquisition and data integration from heterogeneous distributed data, particularly from bio-informatics databases