Shoe design software with an manufacturing-first approach. It separates design, form and measurements. Each can be modified without interfering with the others. The engine in the background combines all three and produces the last, the sole and the flattened pattern to be cut and sewn (or glued) together.
Advanced Simulation Library (ASL) is a free and open source multiphysics simulation software package. Its computational engine is based, among others, on the Lattice Boltzmann Methods (http://en.wikipedia.org/wiki/Lattice_Boltzmann_methods) and is written in OpenCL (http://en.wikipedia.org/wiki/OpenCL) which enable extraordinarily efficient deployment (http://asl.org.il/benchmarks) on a variety of massively parallel architectures, ranging from inexpensive FPGAs, DSPs and GPUs up to heterogeneous clusters and supercomputers. ...
CamelCAM will allow the user (in time, when/if fully functional) to load CAD 3D geometry objects from DXF, IGES and possibly other file formats, choose a particular CNC machine model, set needed parameters and then generate an ISO program suited for that CNC machine, capable of milling/lathing the selected piece.