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Numba is an open source JIT compiler that translates a subset of Python and NumPy code into fast machine code. Numba translates Python functions to optimized machine code at runtime using the industry-standard LLVM compiler library. Numba-compiled numerical algorithms in Python can approach the speeds of C or FORTRAN. You don't need to replace the Python interpreter, run a separate compilation step, or even have a C/C++ compiler installed.

DistAlgo is a very high-level language for expressing distributed algorithms.

Distributed C/C++ compiler for Visual C++

Pyston is a GEM based plugin for GCC that traverses the C/C++ source code and automagically writes thin, fast Python wrappers for all types and functions. These wrappers once created, are independent of the tool and can be directly distributed.