An IRC client that uses Tcl for not only the scripting, but also the "glue" at the C level for how all the parts of the application fit together.
EggControl is a tcl tk application that can be used for: Eggdrop config file generating, channel maitnence, and user maitnence. as well as in the near future advanced botnet setup and hopefully an easy to use scripting interface
Sexy - the multiplatform and user friendly instant communicator project that uses plugins to provide access to the different networks (e.g. IRC, ICQ, Gadu-Gadu, XMPP are planned).
This is a simple RFC 1459 compatible IRC library that uses the socket classes of wxWidgets.