Anope Services are built off of the original Epona code written by Lara which is built off of IRC Services. These services have advanced the original Epona code and include new features such as Modules, Mysql, and Defcon Mode.
A free IRC-based messaging client designed for communication over LAN. The program's look&feel is similar to popular IM clients'. Written in C++ and wxWindows GUI framework. Runs on Linux (GTK+) and Windows.
AjaxChat.org, as its name indicated, is another AJAX chat application that implement many irc commands. The application is written in PHP.
A fork of pidgin which aims to provide minor features that have not been addressed by the pidgin development team (including manual textbox resizing). See funpidgin.sf.net for details.