Nested commands, easy configuration, and an incredibly flexible and easy-to-use plugin system distinguish Supybot from other IRC bots. There simply isn't a more flexible or easier to use IRC bot!
AirBox is service robot that provides various interesting function via MSN Messenger, IRC(RFC1459) chat and J2ME(SKT-XVM). Developed with Java programming language including policy files, dynamic class compile and reloading, web-clawer engine, JDBC etc.
Gribble is the code base for the Supybot SourceForge.net uses for support assistance in the Freenode.net support channel, #sourceforge.
IrcPy is a communication framework based on the syntax of the IRC protocol.
Python IRC Bot
An IRC bot, based on Supybot, designed specifically for use with Foundation: the Game, as well as the FtG forums.
Sugar-Cube is flexible IRC bot which was integrated with Medusa Framework. It gives plugin writers very simple and powerful interface with user database, ACL, m17n, i18n, cron job, session handling, reloadable plugin, persistent database, XMLRPC server.
A perl IRC Bouncer with special add-ons, server list, ipv6 support and much more!
An IRC client that uses Tcl for not only the scripting, but also the "glue" at the C level for how all the parts of the application fit together.
Yogurt is a Python-based multilayered bot framework for IRC/Instant Messenger. It's a descendant of SugarCube but redesigned at all. It will have Web-based configuration/management interface and provide various extensible and stable Plugin/Filter APIs.
IRC-Bot as Interface between http, twitter and IRC:
Full featured, modular IRC bot built from scratch in Python, similar to eggdrop. The internal object oriented IRC library is designed to be both flexible and extensible and is easily separated from the rest of the bot for other projects.
Internet Relay Chat Client, written in Python
pyirclib is an IRC library for Python. It provides basic and advanced characteristics for developing IRC applications
Slaaf is an open source IRC bot. It's built in a way so that every just starting developer can write modules for it.
sushi is an IRC suite providing a central daemon and several clients. It currently consist of - maki: the central IRC daemon - tekka: the PyGTK client - nigiri: urwid terminal client There are more clients to come.
zBot is a modular IRC-Bot written in Python. It includes a small engine to handle IRC communication and user management. It can easily be extended by plugins that add commands and handle events. Some plugins for basic functionality are included.