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Telegram Desktop is the official C++/Qt-based cross-platform client for Telegram, implementing the full Telegram API and MTProto protocol for secure messaging, voice/video calls, file sharing, and chat features. It provides message sync across devices, supports themes, stickers, bots, and is actively maintained.
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No much knowledge in programing required for install, no database is required.
Written in PHP, uses XML as datastoring
OfficeSIP Softphone and Messenger are two enterprise VoIP SIP clients written in C# in .NET Framework. The SIP clients make use of Microsoft UCC API SDK, ensuring the highest quality of audio and video. Compatible with Office Communications Server.
See also open source, cross-platform:
1) simple messenger Brief Msg at http://briefmsg.org
2) MUVConf is a multi-user video conferencing, see demo video http://youtu.be/YrBU-Aqtvrk, download https://code.google.com/p/muvconf/downloads/list
Julia (Jabber User-Level Interface Application) is a Jabber client. The aim of the project is to create a client with MSN-like features (games, animated icons...).
Jabber is developed to be cross-platform, and it runs under Mono.
LLuna2 enables virtual presence on Web sites with animated avatars, video, bubble chat, private chat, and personal profiles. People can meet each other on any Web page. It is based on the Jabber Instant Messaging protocol.