urk is a gnome/gtk irc client written purely in python (but compatible with anything that can run gtk, including windows). It has a simple scripting system, which is used to implement much of the client.
A simple Python IRC client designed with raw access in mind. Designed for good interface without the excessive graphical abstractions found in chatzilla. Windows is not yet supported.
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A framework for creating IRC bots and clients using Python 2 or 3, focusing on ease-of-use and intuition. IRC a low level of raw events and event objects, or a higher level w channel/user objects, as well as thread and commonly used IRC client features.
jig is a console based jabber client. The UI is modeled after bsflite. It will be kept as simple as possible,
while maintaining as many features as possible (GPG encryption, file transfers, etc).
Camio is a multiprotocol and multiplatform IM client developed in Python and GTK. The idea is to get a simple and minimalist client but with support for all the features of the different protocols