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CommuniGeek is a server/client based application for secure chatting on Linux/Windows/MAC, enabling Peer to Peer filetransfer and a GUI using the QT Toolbox.
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
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Ennesbot is an open source automated IRC client (aka Bot) written entirely in Python. It uses direct sockets and medusa style sockets. It has pluggable python personality modules that can extend the bot.
A Python IRC Console Client. I use it to tunnel irc through ssh when I'm at the university. It isn't finished yet, but works quite well for me. The base work is done, but I will revise most of the code soon, so it will be more structured hopefully.
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This is a Python script to parse your irssi logs and input them into a MySQL database which you can then use to search and display your logs on the web. It incrementally updates the database from the logs and is ideally run as a cronjob often.
Kninja is a IRC (Internet Relay Chat) robot that has a extensible interface (by plugins). Kninja is written entirely in Python, so it should be able to run on any computer with Python installed.
PyGG is a library which aims to provide a useful platform for developing clients of Gadu-Gadu (tm), which is the most popular Instant Messanger in Poland.
Muffinbot is an IRC bot that makes having a bot easy. Muffinbot is simple to install, run, configure, and make work for your purposes. The source and plugins are written in PHP. Muffinbot is configured through either the web or the command line.
TwiggiBot can generate stadistics, stores channel logs,coordinates/perfoms a trivial and other many utilities. TwiggiBot can save quite a lot of manual work or can collaborate in several tasks, in short, it could be termed "a butler".
Free IRCX chat server, follows IRCX RFC closely, python, open source. Written by Chris Webb using python in Summer 2006, developers welcome. Please continue to check here regularly for updates
pyPal is a jabber based chatterbot that can be used to launch commands remotely as well as to make some good conversation. It is expected to be capable of multi-language learning.
ultra-xdcc is a XChat-Plugin that supports the xdcc-protocol. That's not all, it has such nice features like: managing downloads, saving download-list on exit, loading download-list on startup ...
ScriptBot is a scriptable IRC bot. Based on PircBot and BSF, it allows to fully customize the bot's behaviour by editing script files in the scripting language of your choice.