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Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
A X-chat plugin written in Python that is a front end for the SD Serving Protocol (SDFind).
This is intended to be a MAC/Linux Friendly alternative to mIRC's OmenServe.
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
Ennesbot is an open source automated IRC client (aka Bot) written entirely in Python. It uses direct sockets and medusa style sockets. It has pluggable python personality modules that can extend the bot.
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Kninja is a IRC (Internet Relay Chat) robot that has a extensible interface (by plugins). Kninja is written entirely in Python, so it should be able to run on any computer with Python installed.
Muffinbot is an IRC bot that makes having a bot easy. Muffinbot is simple to install, run, configure, and make work for your purposes. The source and plugins are written in PHP. Muffinbot is configured through either the web or the command line.
Free IRCX chat server, follows IRCX RFC closely, python, open source. Written by Chris Webb using python in Summer 2006, developers welcome. Please continue to check here regularly for updates
OpenMMOd is a open-source event-driven MMORPG Server written in C++ with a YAML packet definition backend. It is MySQL database driven currently with future backend support to come in the future.
OpenSource mud client designed to work on both windows,linux and MAC OS X. Written in Gtk+ and C with SQLLite, Python, MSP, MXP, HTML, and ZMP support. Provides plugin support, automapper functionality, triggers, aliases and macros.
Pycocha is a standalone chatserver written in python, it is console based, no gtk at moment. You have a chat client and a chat server. Some functions are: help, logging, private massage, topic, register, auth and much more ..
py_xdb_auth is a small but robust jabber-component based on twisted to authenticate jabber users against ldap. It is written for jabberd 1.4 and based on twisted and python-ldap.
Open implementation of the Lotus Sametime protocol
THIS PROJECT HAS MOVED
Please visit https://github.com/obriencj/meanwhile
The Meanwhile project is an open implementation of the Lotus Sametime client protocol. The project provides a library written in C, a python module, and a Gaim plugin utilizing the library.
a small (but many features) chat server and client package program written entirely in python. has somewhat IRC like commands, and the user is identified by his IP when message is sent.
pebwun is a hack of the console MSN Messenger client pebrot written in python. It offers many advanced features such as XMMS controle, lots of color, and many other things. It should work on anything with curses, and is useable with cygwin on windows.
palaver is a p2p multiuser chat program which does not require a central server. It is written in the portable python language, and as such can run unmodified on many platforms.
Concurrence is a networked file editing program that enables multiple people to modify a document simultaneously. It is written entirely in Python, and uses the wxPython library for the GUI and the Twisted library for networking.