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Craybot is a relatively simple, multipurpose IRC bot written in Python with Twisted. Twisted (http://twistedmatrix.com/trac/) is required to use the bot. Documentation may be found at http://tinyurl.com/craybot2doc
Honey IRC Drone is an IRC bot/drone (written in python) that sits on a botnet's IRC command and control server. The purpose is to simulate an actual bot from the botnet and monitor activities.
Pitsilemu is an IRC bot originally designed by the Wikipedia user Pasqual as orejotas and geni. It was translated to English and made available to public by Diego Grez, and modified to be used on Wikinews IRC channel.
This bot is no longer updated, as of August 2015, but may still work.
General and simple IRC bot framework with very flexible bus architecture and plugins support, originally written for use as RPC gateway for remote message sending to multiple IRC channels or users. Now: http://github.com/martinkozak/pyircgate-daemon.
Jabber Bot which provides interface to telnet connection (over 23). Besically it allows interaction with some MUDs or Talkers over the IM clients (pidgin, gajim, gtalk, etc).
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
Ennesbot is an open source automated IRC client (aka Bot) written entirely in Python. It uses direct sockets and medusa style sockets. It has pluggable python personality modules that can extend the bot.
An IRC logging bot, created to be easy to use and simple to configure. The bot comes with a powerful web interface, which through fancy graphs and number illustrate the statistics and logs of both the activity of the user and the channel.
This IRC-Bot is designed to automatically take a special status variable from an cod4 server running the PAM4.02 mod thats called an __pam_ticker. It will then format it to readable text and send this text to a specified irc-channel.
Muffinbot is an IRC bot that makes having a bot easy. Muffinbot is simple to install, run, configure, and make work for your purposes. The source and plugins are written in PHP. Muffinbot is configured through either the web or the command line.
ScriptBot is a scriptable IRC bot. Based on PircBot and BSF, it allows to fully customize the bot's behaviour by editing script files in the scripting language of your choice.