Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
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"dBird Notifier" (with interactive pop-up tray icon) shows incoming messages of the following types: email (thunderbird), twitter and icq (pidgin) - both visually with system message and RGB-LED attached to serial/usb port (hardware details included)
A Python IRC Console Client. I use it to tunnel irc through ssh when I'm at the university. It isn't finished yet, but works quite well for me. The base work is done, but I will revise most of the code soon, so it will be more structured hopefully.
This IRC-Bot is designed to automatically take a special status variable from an cod4 server running the PAM4.02 mod thats called an __pam_ticker. It will then format it to readable text and send this text to a specified irc-channel.
jig is a console based jabber client. The UI is modeled after bsflite. It will be kept as simple as possible,
while maintaining as many features as possible (GPG encryption, file transfers, etc).
PyGG is a library which aims to provide a useful platform for developing clients of Gadu-Gadu (tm), which is the most popular Instant Messanger in Poland.
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TwiggiBot can generate stadistics, stores channel logs,coordinates/perfoms a trivial and other many utilities. TwiggiBot can save quite a lot of manual work or can collaborate in several tasks, in short, it could be termed "a butler".
ScriptBot is a scriptable IRC bot. Based on PircBot and BSF, it allows to fully customize the bot's behaviour by editing script files in the scripting language of your choice.
VVOIP is voice and video over IP is a P2P application without any protocol like SIP (no server is required) etc.. application. It use decent codecs for video and voice encrypted streams over IP. Moreover it is also comptiable with VoIP modems, you'd con
AoCBot is a python bot that wraps together IRC and the Age of Conan chatserver. It has some helpful AoC-related features like whois/IRC relay, and offers a very easy way to add your own plugins.