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BBot is a GNU GPL IRC bot for everything from preventing spam to just plain old welcome bots. BBot includes modules to handle factoids, away statuses, do math and more. Writing custom code for BBot is easy, and the more, the better.
callbot is an IRC bot writen in python to help out some irc friends playing eRepublik.
For more information and the source code please go to http://93.183.131.3/python/callbot
...It is a multi-protocol chatbot distributed under the GPLv3. A very powerful plugin system, multi language support and a simple configuration are only some features of this chat bot.
HTML/CGI-based streaming multi-room CHAT. Crazy administration features (why kick when you can possess?), memos, memo lists, smileys, dice roller, & more. Comes with BOT GAMES and an interface for new bots. In Python, for UNIX and Windows.
Craybot is a relatively simple, multipurpose IRC bot written in Python with Twisted. Twisted (http://twistedmatrix.com/trac/) is required to use the bot. Documentation may be found at http://tinyurl.com/craybot2doc
Honey IRC Drone is an IRC bot/drone (written in python) that sits on a botnet's IRC command and control server. The purpose is to simulate an actual bot from the botnet and monitor activities.
Pitsilemu is an IRC bot originally designed by the Wikipedia user Pasqual as orejotas and geni. It was translated to English and made available to public by Diego Grez, and modified to be used on Wikinews IRC channel.
This bot is no longer updated, as of August 2015, but may still work.
General and simple IRC bot framework with very flexible bus architecture and plugins support, originally written for use as RPC gateway for remote message sending to multiple IRC channels or users. Now: http://github.com/martinkozak/pyircgate-daemon.
Jabber Bot which provides interface to telnet connection (over 23). Besically it allows interaction with some MUDs or Talkers over the IM clients (pidgin, gajim, gtalk, etc).
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.