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Sugar-Cube is flexible IRC bot which was integrated with Medusa Framework. It gives plugin writers very simple and powerful interface with user database, ACL, m17n, i18n, cron job, session handling, reloadable plugin, persistent database, XMLRPC server.
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PjBOT is a fun-oriented irc bot. It does trivial (making statistics of the results, creating a webpage) and in the near future more games.
It is developed in Python. It's Multiplatform and GPL.
PyOP (Python Optimus Prime bot) is an Open Source IRC bot written in Python. It's intended to be simple, fast and modular.
Support for jabber/MSN is planned.
AoCBot is a pythonbot that wraps together IRC and the Age of Conan chatserver. It has some helpful AoC-related features like whois/IRC relay, and offers a very easy way to add your own plugins.