sushi is an IRC suite providing a central daemon and several clients. It currently consist of - maki: the central IRC daemon - tekka: the PyGTK client - nigiri: urwid terminal client There are more clients to come.
XalesBot is a high-performance IRC bot with full scripting support via the Lua language. It is designed for simplicity and ease of use - all functionality excluding communications with the IRC server are handled by Lua, and can be reloaded on-the-fly
IRC Services with Live MySQL support (only running with a MySQL5.0 Server or higher), orion also supports modules and defcon (and many more features), it also includes a webinterface. Commands are based on Anope-syntax
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Tcldrop is basically a clone of the Eggdrop IRC bot, but is being written purely in Tcl. The intention is to write a much more scriptable bot than Eggdrop is. It will run stand-alone or from any Tcl-enabled application (Tcl v8.5+).
PHP IRC-Bot is my first open source project. It's wtitten in PHP5, it's modular Bot, configurable, multi-server and, I hope, safe ! You can develop plugins easily. All functionality mot yet implemented, I work harder !
JJBot is a Jabber Bot written in Java, therefore the name `doh. However, it is long not finished, and I`d be glad is there are some interested peaople willing to help with maybe feature requests.
xtalk is a multi-user IM/chat room system. It can be used to chat with other people within a colourful yet minimalistic command-oriented client. An xtalk server runs continuously at mafianode.com.
synIRCd is a C++ Open Source IRC Daemon / Framework based around an IRC3 protocol 'design'. (Project has no affiliation to synIRC network and is completely separate).
Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
Lost Bot is an IRC Mafia Game Bot coded in TCL. Users register and start off in a 2D city trying to exhort businesses, buying weapons and killing each other. The more respect you gain, the more powerful you are. It will contain a webserver.