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Craybot is a relatively simple, multipurpose IRC bot written in Python with Twisted. Twisted (http://twistedmatrix.com/trac/) is required to use the bot. Documentation may be found at http://tinyurl.com/craybot2doc
Honey IRC Drone is an IRC bot/drone (written in python) that sits on a botnet's IRC command and control server. The purpose is to simulate an actual bot from the botnet and monitor activities.
A framework for creating IRC bots and clients using Python 2 or 3, focusing on ease-of-use and intuition. IRC a low level of raw events and event objects, or a higher level w channel/user objects, as well as thread and commonly used IRC client features.
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General and simple IRC bot framework with very flexible bus architecture and plugins support, originally written for use as RPC gateway for remote message sending to multiple IRC channels or users. Now: http://github.com/martinkozak/pyircgate-daemon.
Pierce is an open source event based framework for building IRC bots (or potentially clients?). It is written in Python and contains default handlers as well as some extra handlers that make bot creation simple.
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A X-chat plugin written in Python that is a front end for the SD Serving Protocol (SDFind).
This is intended to be a MAC/Linux Friendly alternative to mIRC's OmenServe.
Madcow is an extensible IRC/SILC/AIM bot written in Python. It is fully customizable and has a simple API for creating modules that extend its functionality. This project has moved to: http://code.google.com/p/madcow/
Ennesbot is an open source automated IRC client (aka Bot) written entirely in Python. It uses direct sockets and medusa style sockets. It has pluggable python personality modules that can extend the bot.
Kninja is a IRC (Internet Relay Chat) robot that has a extensible interface (by plugins). Kninja is written entirely in Python, so it should be able to run on any computer with Python installed.
Muffinbot is an IRC bot that makes having a bot easy. Muffinbot is simple to install, run, configure, and make work for your purposes. The source and plugins are written in PHP. Muffinbot is configured through either the web or the command line.
Free IRCX chat server, follows IRCX RFC closely, python, open source. Written by Chris Webb using python in Summer 2006, developers welcome. Please continue to check here regularly for updates
OpenMMOd is a open-source event-driven MMORPG Server written in C++ with a YAML packet definition backend. It is MySQL database driven currently with future backend support to come in the future.
OpenSource mud client designed to work on both windows,linux and MAC OS X. Written in Gtk+ and C with SQLLite, Python, MSP, MXP, HTML, and ZMP support. Provides plugin support, automapper functionality, triggers, aliases and macros.
Pycocha is a standalone chatserver written in python, it is console based, no gtk at moment. You have a chat client and a chat server. Some functions are: help, logging, private massage, topic, register, auth and much more ..