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Whitebeam is a complete rapid development Web application server integrating Apache, Posgresql, Mozilla's SpiderMonkey JavaScript engine with it's own powerful XML/XPath based secure application framework.
Porcupine is an open-source Python based web application server that provides front-end and back-end revolutionary technologies for building modern data-centric Web 2.0 applications.
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A Perl based lightweight application controller framework which uses XML to store individual application's configuration, functionality, behaviour and messaging, and uses XSLT to transform XML data structures into vanilla web management interfaces
Salto framework is an AJAX based framework which makes possible to build a Web application very quickly.
Thanks to AJAX mechanism, datas exchanges between client side an server side are reduced. You are able to refresh only a part of the screen.
GateRoom is a real MVC framework. The only one which also thrives to divide between server code and client code completly. Those creating a loose framwork (or collection of tools) to create web sites and web application with the newest of techs available.
Openology's goal is to provide a way to integrate the many open source PHP web applications. Integation consist of the frontend design and the backend code integration.
The Floranta libraries provide components for building Rich Client Wikis using AJAX or Java. Floranta clients can be embedded in any webpage (even plain html) and allow users to leave notes, images, cards, etc on the pages. Eg: http://www.floranta.com
SWAS is the Simple Web Application System, a web database-based application development framework:
+The best form-based web-database interface
+Easy report generation
+Templating language: SWAL (Simple Web Application Language)
Php Window System is a generic Window management PHP code that allow any PHP application to propose to the user a friendly graphical interface.
Php Window System manage the main window, the title header, menu bars with sub-menus, footers, popup windows .
Hayta-UML is a Web2.0 UML tool, that allows users to draw UML diagrams. A core design decision is to have a native version-control inside the application.
A mod_perl-based RPC API designed for ease of setup, ease of extension, and rapid development.
Using Presto, you can develop a robust, fully "web-2.0" web application in a day or two.
Oh and it scales.
Take that, Ruby on Rails.