Woofy is a pretty neat webcomic downloader, designed for simplicity and ease of use. Its purpose is to help you download and keep an archive of your favorite online comics, while not getting too much in your way.
OpenComic is a CMS built primarily for webcomic websites. It uses templates to give a highly customized experience as well as a comprehensive and easy to use administration panel. It also carries a mass update client and a local update daemon.
Comic.NET is a WebComic CMS written in ASP.NET and C#. It povides a flexible solution, easy to adapt to any kind of setup. It uses Textile formatting by default for news/blog entries. The Textile formatter is available as a standalone library.