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A cross-platform Point-Of-Sale (for retail environments) written in Python, with a keyboard-driven graphical interface.
It can run as a standalone system, or interact with multiple backends.
http://qualitypos.qbcon.com/
BLIX is a cross-platform set of Python extension modules and Python scripts for Blender (www.blender.org). These scripts add camera calibration, 3D reconstruction and rigid body orientation to Blender.
OpenRMS is an open source reservation management system for small hotels and bed&breakfasts. It is written in Python and PHP, is cross-platform and supports multiple database backends. The web components allow for electronic booking online.
TeXPerfect plans to be a cross-platform, extensible, user-friendly yet expert-tunable visual TeX implementation. The most important feature will be a split screen (inspired by WordPerfect(R) Reveal Codes) showing the underlying TeX code.