Feathers
Framework for real-time applications and REST APIs with JavaScript
... but is flexible enough to not be in the way. Feathers is a “batteries included but easily swappable framework” with a large ecosystem of plugins. Include exactly what you need. No more, no less. Feathers has adapters for 12+ databases out of the box. You can have multiple databases in a single app and swap them out painlessly due to a consistent query interface. Feathers can be used the same way on the server with Node.js and in the browser with frameworks like React, Angular, VueJS or on mobile with React.