Search Results for "syntax tree model"

...Based on SNP alleles calls and locations, it breaks the genomes into locally colinear blocks, and looks for cases where SNPs do not agree with the vertical pattern of inheritance in a phylogeny. It applies a dynamic programming algorithm to model whether changes within a block are likely a result of mutations, sequencing errors, or HRE. We use information from the nearby SNPs, so that if 1-2 alleles in a series of SNPs differs from the ancestral allele, it may be better explained as a mutation or sequencing error. But if a series of SNP alleles differ from the ancestral pattern, then it may be more likely that an HRE has occurred, particularly if the allele pattern matches that from another part of the tree better than that of the ancestral node.

SpikeyTree infers divergence times between populations that share a common history described by a tree. SpikeyTree assumes that the populations have been evolving under isolation, according to the Wright-Fisher with pure drift. SpikeyTree can use the Beta or the Beta with Spikes approximation to the allele frequency distribution under the Wright-Fisher. More details can be found in Tataru et al. Inference under a Wright-Fisher model using an accurate beta approximation If using this software in a publication, please cite the above article.