Showing 4 open source projects for "off-site.com"

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  • 1
    Protenix

    Protenix

    A trainable PyTorch reproduction of AlphaFold 3

    ...Protenix provides a complete pipeline for turning protein sequences (with optional MSA / sequence alignment) or structural inputs (e.g. PDB/CIF) into full 3D atomic-level structure predictions. It supports both “full” models and lightweight variants such as “Protenix-Mini,” offering a trade-off between speed/compute cost and predictive accuracy — making structure prediction accessible even in resource-constrained environments. The project also includes support for constraints (e.g., specifying residue- or atom-level contact constraints, or pocket constraints) to guide predictions toward biologically or experimentally relevant conformations, which enhances its utility for tasks like modeling complexes, ligands, or antibody–antigen interactions.
    Downloads: 1 This Week
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  • 2
    siFi21

    siFi21

    si-Fi is a Software for RNAi (RNA interference) off-target prediction.

    si-Fi is a Software for RNAi (RNA interference) off-target prediction The software is designed for checking long-double stranded RNAi constructs for target specificity and silencing efficiency. It can be used also to select sequence regions suitable for designing RNAi constructs. The program provides clear tabular and graphical outputs.
    Downloads: 23 This Week
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  • 3
    Stochastic Rule Builder (SRB)

    Stochastic Rule Builder (SRB)

    Modeling framework for capturing positional and temporal dynamics

    ...All the possible actions are based on the current state of factors bound to the DNA. We developed a rule builder to automatically generate the complete set of biochemical interaction rules for any given DNA sequence. Off-the-shelf stochastic simulation engines can model the behavior of a system of rules and the resulting changes in the configuration of bound factors can be visualized.
    Downloads: 0 This Week
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  • 4
    Protospacer

    Protospacer

    Rapid gRNA design and validation for CRISPR

    ...Protospacer then allows the user to sub-select targets from the database by gene ID, by exon/intron/UTR location, by sequence similarity, or by genomic co-ordinate. From here, users are able to evaluate potential off targeting, to export results in FASTA format or tabulated (e.g. for Microsoft Excel), and to connect to the Integrative Genomics Viewer (IGVref) and view target-sites in the context of genomic annotations, amino acid translations, and HT-Seq data (for off-target validation). We provide online video tutorials and a toy database from our main website.
    Downloads: 0 This Week
    Last Update:
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