...EigenMS utilizes SVD to detect bias trends in the data and eliminates them. EigenMS eliminates effects from known and unknown factors and can be utilized for any -omic platform.
We have shown its utility in LC-MS/MS and metabolomics in the following two papers:
1) PMID: 19602524. "Normalization of peak intensities in bottom-up MS-based proteomics using singular value decomposition".
Karpievitch YV, Taverner T, Adkins JN, Callister SJ, Anderson GA, Smith RD, Dabney AR.
Bioinformatics 2009
2) "Metabolomics data normalization with EigenMS"
Karpievitch YV, Nikolic SB, Wilson R, Sharman JE, Edwards LM.
...