Locsmoc produces piecewise polynomial models for one-dimensional signals of the type encountered in genomics.
The project wiki contains an overview of the tool and usage examples.
Software for making Clusters of Orthologous Groups (featuring the new EdgeSearch algorithm). Latest ref: Kristensen DM, Kannan L, Coleman MK, Wolf YI, Sorokin A, Koonin EV, Mushegian A. Bioinformatics 2010.