fitGCP
Fitting genome coverage distributions with mixture models
Genome coverage, the number of sequencing reads
mapped to a position in a genome, is an insightful indicator of irregularities within sequencing experiments. While the average genome coverage is frequently used within algorithms in computational
genomics, the complete information available in coverage profiles (i.e. histograms over all coverages) is currently not exploited to its full extent. Thus, biases such as fragmented or erroneous reference
genomes often remain unaccounted for....