Now maintained at github.com/spacepy/spacepy
Space Science library for Python - contains superposed epoch classes, drift shell tracing, access to magnetic field models, streamline tracing, bootstrap confidence limits, time and coordinate conversions, etc.
RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
The MYRaf is a practicable astronomical image reduction and photometry software and interface for IRAF. For this purpose, MYRaf uses iraf, PyRAF and alipy via great programming language Python and Qt framework. Also MYRaf is a absolutely free software and distributed with GPLv3 license. You can use it without restrictive licenses, make copies for your friends, school or business.
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pyastrolib is a python library providing professional astronomers a robust set of tools for astronomical data analysis. This project will provide all the functionality as NASA's IDL Astronomy User's Library in addition to other planned features.
GIRAFFE Base Line Data Reduction Software is a set of python scripts and modules
and a C library to reduce FITS images produced by the Very Large Telescope (VLT)
FLAMES instrument.
PyXPA is a Python interface to the XPA library (http://hea-www.harvard.edu/RD/xpa/ developed by the SAO/HEAD R&D Group (http://hea-www.harvard.edu/RD/)).