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RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
AstroTortilla is a wrapper around common astrophotography tools intended to automate basic tasks such as polar alignment and goto correction.
Not in active development presently.
GIRAFFE Base Line Data Reduction Software is a set of python scripts and modules
and a C library to reduce FITS images produced by the Very Large Telescope (VLT)
FLAMES instrument.
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NTuple is a Python module used by high-energy physicists and astrophysicists to easily and efficiently access ntuple data stored in large ROOT data stores. Specifically, NTuple provides a friendly Pythonic interface to TNtuples and TTrees stored in TFiles