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RTS2 is project to create an open source environment for control of a fully autonomous observatory. It is running about dozen fully autonomous observatories. Its modular design allow easily addition of new devices (to already huge supported HW list).
GIRAFFE Base Line Data Reduction Software is a set of python scripts and modules
and a C library to reduce FITS images produced by the Very Large Telescope (VLT)
FLAMES instrument.
NTuple is a Python module used by high-energy physicists and astrophysicists to easily and efficiently access ntuple data stored in large ROOT data stores. Specifically, NTuple provides a friendly Pythonic interface to TNtuples and TTrees stored in TFiles