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OntoCardio is an initiative to build ontologies for the legacy Cardio Database (Resource of bioinformation on cardiovascular diseases). SMI's Protege and its OWL plug-in has been adopted as the ontology construction and programming framework.
GrOWL is a visualization and editing tool for OWL and DL ontologies. GrOWL aims to reconcile modern ontology language OWL with old semantic network philosophy by providing a set of graphic idiom that cover almost every OWL construct.
Top Engine the Semantic Web Engine for the Enterprise. Top Engine is a Business Rule Engine that utilize OWL DL ontologies for vocabulary primitive to write rules on top of ontology. Top Engine support forward and backward chaining with truth maintenance
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The OBO-Annotator is a semantic NLP tool that is designed to give its end-users a great deal of flexibility to combine any number of OBO ontologies from the OBO foundry regardless of their format and use them to annotate text-bases.