KlayGE is an open source, cross-platform game engine with plugin-based architecture. It provides a framework to make game development, testing, porting as simple as possible.
Spineless is a generic cross-platform 3D game engine implemented in Python. Focus is on flexibility, clean design and ease of use, not pure speed or bleeding edge graphics.
MayaVi is a free, cross platform, easy to use scientific data visualizer. It provides a GUI to ease the visualization process, is written in Python and uses the Visualization Toolkit (VTK) for the graphics.
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TinyGL on SDL is a free implementation of TinyGL library (mini-openGL) under multiplatform SDL library. Also, it is a fixed-point fast implementation for low platform as GP32 console.