SPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).
A second version has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor gain (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
Both implementations of SPINA have been validated in clinical studies on the basis of large cohorts.
Features
- More than 25 years of continued development
- Based on published parametrically isomorphic model of thyroid and insulin-glucose homeostasis
- Algorithm evaluated in multiple clinical trials with thousands of patients
- Suport for different units of measurement
- Data import and export in HL7 format
- Curated by SciScrunch, OpenAIRE and Zenodo
- Cross-platform for Mac OS Classic, macOS (Mac OS X), Windows, Linux and Palm OS / Garnet OS
- DOI 10.5281/zenodo.3596049 https://doi.org/10.5281/zenodo.3596049
License
BSD LicenseUser Reviews
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I am trying to use the version for iMac which is file version 4.2.1.875 with Cocoa widget set but it doesn't have an option to set preferences so that I can input reference ranges for TSH, FT4 and FT3 as I know the Windows version does. Is this an oversight?Reply from SPINA
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Can't download it in Mac - says it needs to be updated and can't check it for malicious software. I'm really looking forward to trying this out in the future and hope it can be fixed.Reply from SPINA
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Unable to run on MACReply from SPINA
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I downloaded it but MacOS says it cannot be checked for malicious spyware and so it will not open. I hope this can be fixed as I was really looking forward to trying this program!Reply from SPINA
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Uses this tool to get a more specific view of thyroid data - very nice tool