The "de-ADP-ribosylation", really mono-ADP-ribosylhydrolase activities, are not the inverse reactions of ADP-ribosylation reactions. ADP-ribosylation utiliizes NAD(+) to attach the ADP-ribosyl group and liberate nicotinamide which is quickly scavenged, making that reaction thermodynamically irreversible in vivo. These "de-ADP-ribosylation" reactions are simple hydrolytic...
2013-05-08 09:42:02 PDT in Proteomics Standa...
