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Hmm... it looks like error-free predates this discussion?.
2009-10-29 17:10:40 UTC in Gene Ontology
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My only concern is that I don't like calling anything in biology "error-free". I can't imagine that the "error-free" processes are really error-free. I am guessing that they just have error rates many orders of magnitude lower than the Y-family translesion DNA polymerases. Is there another way to say this? I'll seek an opinion via email to some experts.
2009-10-29 16:56:24 UTC in Gene Ontology
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This is the same as GO:0008976 ! polyphosphate kinase activity
Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1].
2009-09-18 18:21:07 UTC in Gene Ontology
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Note that there is not a termination codon encountered in the canonical cases where tmRNA rescues the ribosome, and the termination codon that actually releases the ribosome is at the end of the tagging peptide. I think the problem is that biochemically termination is a special case for what happens when an aa-tRNA cannot be delivered to the A site, but in terms of how we think about processes...
2009-09-11 16:18:05 UTC in Gene Ontology
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child of GO:0006464_!_protein_modification_process
Definition: cotranslational addition of a polypeptide to a nascent polypeptide by trans-translation.
We would like this to be a child of protein modification process rather than a child of GO:0043686 - co-translational protein modification because co-translational protein modification implies modification of a previously incorporated amino...
2009-09-10 16:14:31 UTC in Gene Ontology
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New child of GO:0006414 translational_elongation
Definition:transfer of a translating ribosome from one mRNA to another RNA template.
PMID: 12730326
Occurs during tmRNA release of stalled ribosomes.
2009-09-10 16:11:36 UTC in Gene Ontology
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New Biological Process term
Possible definition: Any process that allows ribosomes to escape from stalled states during translational elongation
Not sure where this should go:
Ribosomes are unable to release from mRNAs that lack a stop codon, such as those that occur due to endonucleolytic cleavage of mRNA during translation. tmRNAs release ribosomes from the ends of such broken mRNAs by...
2009-09-10 16:08:54 UTC in Gene Ontology
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New child of GO:0043488 regulation of mRNA stability
Definition: Any process, mediated by small ncRNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
Reference: Gottesman (2004) Ann Rev. Microbiol.
doi:10.1146/annurev.micro.58.030603.123841
This new term request follows up a conference call on annotation of...
2009-09-10 16:04:24 UTC in Gene Ontology
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jimhu added muruganujan to the EcoliHub project.
2009-08-17 21:57:29 UTC in EcoliHub
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jimhu committed revision 1 to the EcoliHub SVN repository, changing 1 files.
2009-06-24 23:11:54 UTC in EcoliHub
