phPOP3clean

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What did you set PHPOP3CLEAN_QUARANTINE to in phPOP3clean.config.php?
If you set it to
"http://www.mydomain.com/pop3clean/phPOP3clean/quarantine/" then that's
wrong, you need to set it to the actual absolute path on your server, which
will be something more like
"/home/httpd/mydomain.com/httpdocs/pop3clean/phPOP3clean/quarantine/"

Following your advice I have define PHPOP3CLEAN_QUARANTINE in
phPOP3clean.config.php with
the full path, not using $_SERVER but the problem remains.
This is the new e-mail error I have received:

FAILED:
mkdir(http://www.mydomain.com/pop3clean/phPOP3clean/quarantine/200612)

Sounds like PHPOP3CLEAN_QUARANTINE (in phPOP3clean.config.php) may not be
set up correctly, most likely if $_SERVER['DOCUMENT_ROOT'] does not resolve
correctly. My best guess is that PHPOP3CLEAN_QUARANTINE is being set to
"/pop3clean/phPOP3clean/quarantine/" rather than something like
"/home/httpd/vhosts/example.com/httpdocs/pop3clean/phPOP3clean/quarantine/".
If neccesary, define PHPOP3CLEAN_QUARANTINE in phPOP3clean.config.php with
the full path, not using $_SERVER['DOCUMENT_ROOT'].