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Virtual Microdissection for SNP calling

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11-07-2013 A new version Virmid 1.1.0 has been uploaded.
08-29-2013 Virmid paper is now published in Genome Biology.
Kim S et al, "Virmid: accurate detection of somatic mutations with sample impurity inference", Genome Biology 2013, 14:R90

Virmid (Virtual Microdissection for SNP calling) is a Java based variant caller designed for disease-control matched samples. Virmid is also specialized for identifying potential within individual contamination where the disease sample cannot be purified enough. While the SNP calling rate is severely compromised with this heterogeneity, Virmid can uncover SNPs with low allele frequency by considering the level of contamination (alpha). The important features of Virmid are:

•Estimation of accurate proporation of control sample in a (mixed) disease sample
•Improved SNP and somatic mutation calling with regard to the estimated proportion

Virmid Web Site


  • Somatic mutation finding
  • Sample impurity inference

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